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Synthesis of Isoxazole Moiety Containing Thieno[2,3-d]pyrimidine Derivatives and Preliminarily in vitro Anticancer Activity (Part II)
21 new structures of isoxazole-moiety-containing thieno[2,3-d]pyrimidine derivatives(3a~3u) were synthesized for the first time and characterized using IR, 1H NMR, 13C NMR, ESI-MS and elemental analysis techniques. And then their in vitro anticancer activity against lung cancer A549, colorectal HCT1
Recent Advances in Phenanthroindolizidine and Phenanthroquinolizidine Derivatives with Anticancer Activities
Phenanthroindolizidine and phenanthroquinolizidine derivatives constitute a series of compounds that are being intensively studied as potential anticancer agents. Related natural products such as antofine and tylophorine alkaloids are well known for their high cytotoxic activity; however, their clin
New Potentiometric Iron(III)-selective Electrode Based on a Tris(Aminophenolate) as a Sensing Molecule
A novel PVC-incorporated membrane electrode selective for iron(III) is described. The sensor is based on the use of novel tris(aminophenolate) sensing molecule Cis,cis-1,3,5-tris{(2- hydroxybenzyl)aminomethyl}cyclohexane (THAC, L). The optimized membrane containing THAC, PVC and o-nitrophenyloctyl e
Anti-Inflammatory Activity of Polysaccharide Fraction of Curcuma longa Extract (NR-INF-02)
The aim of the study was to investigate the safety and anti-inflammatory effects of polysaccharide fraction (F1) of Curcuma longa extract (NR-INF-02) in classical rodent models of inflammation. F1 was evaluated for its acute oral toxicity and found to be safe upto 5000 mg/kg body weight in rats. The
Structure-based Discovery of Novel Antibacterials
An increasing fraction of bacterial isolates show reduced susceptibility to our most trusted antibiotics. In order to prevent this serious medical problem, the elaboration of new types of antibacterial agents or the expansion of bioactivity of the previous drugs is a very important task. Different t
Neddylation Pathway as a Novel Anti-cancer Target: Mechanistic Investigation and Therapeutic Implication
Protein neddylation, a newly characterized posttranslational modification that adds the ubiquitin-like molecule NEDD8 to substrates, modulates important biological processes, whereas dysfunction of neddylation may cause several serious diseases, such as cancer. Inhibition of neddylation pathway has
A Simple and Sensitive Hydrazine Electrochemical Sensor Based on Platinum Nanoclusters
In this paper, platinum nanoclusters (PtNCs) were synthesized by less sophisticated equipments with low cost and tedious procedures, and then applied to construct a simple electrochemical hydrazine sensor rapidly within the applied potential. PtNCs were proved to have advantages over platinum nanopa
Synthesis of Some New Monocyclic β-Lactams Bearing a Morpholine Moiety at their N1 Positions as Antifungal Agents
The synthesis of 40 new monocyclic β-lactams bearing a morpholine moiety at their N1 positions is described. The structures of these compounds have been confirmed by IR, 1H-NMR, 13C-NMR, Mass spectra and Elemental analysis. The antimicrobial activities of the synthetic compounds have been teste
Investigation of 2-Fluoro Benzoic Acid Derivatives as Influenza A Viral Sialidase Selective Inhibitors
Neuraminidase (NA), a glycoside hydrolase enzyme, plays pivotal roles in controlling biological functions not only of influenza viruses but also of humans. Zanamivir and oseltamivir designed to target influenza neuraminidase have become extensively used for influenza clinical treatment as its high a
Synthesis and in vitro Evaluation of Polymeric Prodrug of Ibuprofen with Amino Acid Spacer
The present work is an agreement with simple and efficient method of improving the therapeutic efficacy of ibuprofen by masking its acidic moiety. It aims to reduce gastrointestinal side effects by controlling the rate, duration and site of release. This is achieved by synthesis and evaluation of po
Emerging Antimicrobial Applications of Nitric Oxide (NO) and NO-Releasing Materials
During the past few decades, the potential of treating infections with nitric oxide (NO) has been firmly demonstrated in various laboratories. Both in vitro and in vivo studies have afforded promising results in terms of reducing microbial loads in chronic wounds in addition to its utility in keepin
Synthesis and characterization of a new retinoic acid ECPIRM as potential chemotherapeutic agent for human cutaneous squamous carcinoma
Cutaneous squamous cell carcinoma (CSCC) is one of the most common cancers worldwide, requiring effective therapeutic interventions. Retinoids are important chemopreventive and therapeutic agents for a variety of human cancers including CSCC. In this study we synthesized a novel retinoic derivative
Determination of Carprofen in the Presence of some Hydrosoluble Vitamins of Group B by HPLC Method
A new HPLC method have been developed and validated for simultaneous determination of carprofen, vitamin B1, B6 and B12 in veterinary pharmaceutical preparations medicines. The method used a Hypersil GOLD aQ (250 x 4.6 mm, 5 µm) column, under the following chromatographic conditions: gradient e
Quercetin Increase the Chemosensitivity of Breast Cancer Cells to Doxorubicin Via PTEN/Akt Pathway
Our previous study indicated that nontoxic doses of quercetin (Que) could increase the chemosensitivity of breast cancer cells to doxorubicin (Dox) although the mechanism still remains elusive. Therefore, in this study, we aimed to investigate the underlying mechanisms. MCF-7 cells and MCF-7/dox cel

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