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Emerging Antimicrobial Applications of Nitric Oxide (NO) and NO-Releasing Materials
During the past few decades, the potential of treating infections with nitric oxide (NO) has been firmly demonstrated in various laboratories. Both in vitro and in vivo studies have afforded promising results in terms of reducing microbial loads in chronic wounds in addition to its utility in keepin
A Simple and Sensitive Hydrazine Electrochemical Sensor Based on Platinum Nanoclusters
In this paper, platinum nanoclusters (PtNCs) were synthesized by less sophisticated equipments with low cost and tedious procedures, and then applied to construct a simple electrochemical hydrazine sensor rapidly within the applied potential. PtNCs were proved to have advantages over platinum nanopa
Anti-Inflammatory Activity of Polysaccharide Fraction of Curcuma longa Extract (NR-INF-02)
The aim of the study was to investigate the safety and anti-inflammatory effects of polysaccharide fraction (F1) of Curcuma longa extract (NR-INF-02) in classical rodent models of inflammation. F1 was evaluated for its acute oral toxicity and found to be safe upto 5000 mg/kg body weight in rats. The
Exploring Cancer Therapeutics with Natural Products from African Medicinal Plants, Part I: Xanthones, Quinones, Steroids, Coumarins, Phenolics and other Classes of Compounds
Cancer is known to be the second most common disease-related cause of death among humans. In drug discovery programs anti-cancer chemotherapy remains quite challenging due to issues related to resistance. Plants used in traditional medicine are known to contribute significantly within a large propor
A Derivative Method with Free Radical Oxidation to Predict Resveratrol Metabolites by Tandem Mass Spectrometry
In this study, we demonstrated an oxidative method with free radical to generate 3,5,4 -trihydroxy-transstilbene (trans-resveratrol) metabolites and detect sequentially by an autosampler coupling with liquid chromatography electrospray ionization tandem mass spectrometer (LC-ESI–MS/MS). In this ox
Using Silica-titania Xerogels for Solid Phase Spectrophotometric Determination of Fluoride in Oral Hygiene Products
New materials - silica-titania xerogels modified with polyphenols (caffeic acid, catechol, and quercetin) or hydrogen peroxide - have been used for solid phase spectrophotometric determination of fluoride ions. The fast and simple method is based on the xerogel incorporated titanium(IV) complexes di
Recent Innovations of Molecularly Imprinted Electrochemical Sensors Based on Electropolymerization Technique
Electrochemical sensors based on molecularly imprinted polymer (MIP) have attracted great attention over the past ten years. Among the strategies for the preparation of MIP modified electrode, electropolymerization is a potential technique, which can deposit a MIP film with special selectivity on th
Intracellular ROS Generation Mediates Maleimide-induced Cytotoxicity in Leukemia Cells
Maleimides consist of an important class of compounds easily synthesized with multiple functional group modification that provides expressive pharmacological properties including, antitumoral activity, mediated mainly by oxidative stress. For this reason, the present study was designed to evaluate t
Ozone Dosage Effect on C6 Cell Growth: in Vitro and in Vivo Tests
C6 rat glioma cells are one of the most aggressive carcinogenic tumors, due to its high mortality rate in human beings and animals. The current treatment for this illness includes surgery, radio and chemotherapy, showing relapse in patients treated with those therapies. Since the ozone was found to
A Novel Multi-functional Fluorescent Probe for Cu2+, Fe3+ and Ag+ Based on a Pyrimidine Thiourea Derivative
A multi-functional “turn-off” fluorescent probe, N-[[(6-Amino-1,2,3,4-tetrahydro-1,3- dimethyl-2,4-dioxo-5-pyrimidinyl)amino]thioxomethyl]- benzamide, was synthesized and characterized. The probe showed high sensitivity and selectivity towards copper(II), iron(III) and silver(I) ions via quenchi
Synthesis of Some New Monocyclic β-Lactams Bearing a Morpholine Moiety at their N1 Positions as Antifungal Agents
The synthesis of 40 new monocyclic β-lactams bearing a morpholine moiety at their N1 positions is described. The structures of these compounds have been confirmed by IR, 1H-NMR, 13C-NMR, Mass spectra and Elemental analysis. The antimicrobial activities of the synthetic compounds have been teste
Development of Montelukast Sodium Loaded Niosomal Carriers by Film Hydration Technique
The aim of this study was to develop and characterize montelukast sodium loaded niosomal drug carrier systems. The vesicles were prepared by film hydration technique using different surfactants. The optimized formulation was selected on the basis of results obtained from drug entrapment, morphology
Quercetin Increase the Chemosensitivity of Breast Cancer Cells to Doxorubicin Via PTEN/Akt Pathway
Our previous study indicated that nontoxic doses of quercetin (Que) could increase the chemosensitivity of breast cancer cells to doxorubicin (Dox) although the mechanism still remains elusive. Therefore, in this study, we aimed to investigate the underlying mechanisms. MCF-7 cells and MCF-7/dox cel

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