Latest Articles

Immunotherapeutic Impact of Toll-like Receptor Agonists in Breast Cancer
Onset of tumors in breast cancer is a multi-factorial event at different ages and ethnic populations. The conventional treatment strategy suggests use of anti-estrogen drugs and selective estrogen receptor modulators (SERMs). Although, this strategy has achieved significant success to prevent tumor
Novel, Unifying Phagomimetic Mechanism of Vancomycin Therapeutic Action and Toxicity: Polyphenol, Electron Transfer and Reactive Oxygen Species
In recent years, vancomycin has received appreciable attention as an antibiotic drug of last resort. The generally accepted mechanism entails interference with bacterial cell wall synthesis. There is negligible attention to other modes, even though drug action is often multifaceted. This review prov
Development of Montelukast Sodium Loaded Niosomal Carriers by Film Hydration Technique
The aim of this study was to develop and characterize montelukast sodium loaded niosomal drug carrier systems. The vesicles were prepared by film hydration technique using different surfactants. The optimized formulation was selected on the basis of results obtained from drug entrapment, morphology
A Simple and Sensitive Hydrazine Electrochemical Sensor Based on Platinum Nanoclusters
In this paper, platinum nanoclusters (PtNCs) were synthesized by less sophisticated equipments with low cost and tedious procedures, and then applied to construct a simple electrochemical hydrazine sensor rapidly within the applied potential. PtNCs were proved to have advantages over platinum nanopa
Synthesis and in vitro Evaluation of Polymeric Prodrug of Ibuprofen with Amino Acid Spacer
The present work is an agreement with simple and efficient method of improving the therapeutic efficacy of ibuprofen by masking its acidic moiety. It aims to reduce gastrointestinal side effects by controlling the rate, duration and site of release. This is achieved by synthesis and evaluation of po
Cytotoxic, Antiproliferative and Apoptotic Effects of New Benzimidazole Derivatives on A549 Lung Carcinoma and C6 Glioma Cell Lines
Benzimidazole ring is a versatile structure which has been extensively utilized in medicinal chemistry. Since we are working on 1,2-disubstutited benzimidazoles, we have reported new antitumor active derivatives. As a continuation to our previous work, we have synthesized a new series of 1-(2-aryl-2
Synthesis of Some New Monocyclic β-Lactams Bearing a Morpholine Moiety at their N1 Positions as Antifungal Agents
The synthesis of 40 new monocyclic β-lactams bearing a morpholine moiety at their N1 positions is described. The structures of these compounds have been confirmed by IR, 1H-NMR, 13C-NMR, Mass spectra and Elemental analysis. The antimicrobial activities of the synthetic compounds have been teste
Oral Agents in Multiple Sclerosis
Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system. Diseasemodifying drugs licensed for MS treatment have been developed to reduce relapse rates and halt disease progression. The majority of current MS drugs involve regular, parenteral administration, affecting lon
Neddylation Pathway as a Novel Anti-cancer Target: Mechanistic Investigation and Therapeutic Implication
Protein neddylation, a newly characterized posttranslational modification that adds the ubiquitin-like molecule NEDD8 to substrates, modulates important biological processes, whereas dysfunction of neddylation may cause several serious diseases, such as cancer. Inhibition of neddylation pathway has
Investigation of 2-Fluoro Benzoic Acid Derivatives as Influenza A Viral Sialidase Selective Inhibitors
Neuraminidase (NA), a glycoside hydrolase enzyme, plays pivotal roles in controlling biological functions not only of influenza viruses but also of humans. Zanamivir and oseltamivir designed to target influenza neuraminidase have become extensively used for influenza clinical treatment as its high a
Recent Innovations of Molecularly Imprinted Electrochemical Sensors Based on Electropolymerization Technique
Electrochemical sensors based on molecularly imprinted polymer (MIP) have attracted great attention over the past ten years. Among the strategies for the preparation of MIP modified electrode, electropolymerization is a potential technique, which can deposit a MIP film with special selectivity on th
A Derivative Method with Free Radical Oxidation to Predict Resveratrol Metabolites by Tandem Mass Spectrometry
In this study, we demonstrated an oxidative method with free radical to generate 3,5,4 -trihydroxy-transstilbene (trans-resveratrol) metabolites and detect sequentially by an autosampler coupling with liquid chromatography electrospray ionization tandem mass spectrometer (LC-ESI–MS/MS). In this ox
New Potentiometric Iron(III)-selective Electrode Based on a Tris(Aminophenolate) as a Sensing Molecule
A novel PVC-incorporated membrane electrode selective for iron(III) is described. The sensor is based on the use of novel tris(aminophenolate) sensing molecule Cis,cis-1,3,5-tris{(2- hydroxybenzyl)aminomethyl}cyclohexane (THAC, L). The optimized membrane containing THAC, PVC and o-nitrophenyloctyl e

Previous      Next      Results 1 - 15 of 3230